Latest questions:
Trending questions:
Hot questions:
Personalized Medicine - Future
Why is the need of developing personalized medicine?
What is Metabolomics/metabonomics?
What is Pharmacometabonomics?
How Metabolomics & Pharmacometabonomics can be used for designing personalized medicine?
75 months ago
2 answers
Let’s not be too hasty. Considering medicines as a form of consumer goods, we can make a comparison to other situations when items are specifically generated for individuals, for example in clothing. Here you can take “one fits all”, “off the peg”, or “made to measure”. The first one takes no personal features into consideration; the second differentiates between men and women and children in terms of dose but not much else. “Made to measure”, i. e., a personalized version is based on specific parameters of a given individual.
Hence, for a personalized medicine, specifics of a given disease of an individual needs to be determined in mechanistic and structural terms. As in the case if clothing, a “personalized medicine” could be used for any individual that matches the given identified disease mechanism and structured. As of now, current medicine are most similar to the “one fits all” case...
75 months ago
metabolomics is the metabolic chemical profile of a single tissue or cell, whereas metabonomics is the combined metabolic output of an aggregate of cells/tissues, presenting a more complex metabolic profile. These terms should be used differently based on their application, potentially mechanistic (for isolating a particular cell/bacteria and it’s specific metabolites) vs. Correlative (using metabonomics of Gut tissue alongside microbiota sampling for example).
75 months ago
