Latest questions:
Trending questions:
Hot questions:
Where will NK cell based immunotherapies go?
With recent great successes of CAR-T cells, NK cell based immunotherapies seem to attract more attention with a promising future in the field of cancer immunotherapy. With recent advancement in the knowledge of NK cells and improvement in technology of NK cell in-vitro gene manupilation and culture, which direction do you think NK cell based immunotherapy will go in the future?
79 months ago
2 answers
NK cells might be more effective against hematological cancers, residual minimal disease and nascent metastasis, possibly because of their early role, cross-talk with other leukocytes and inability to vigorously proliferate, in contrast to T cells.
79 months ago
Interesting clinical trials regard Anti-cancer who can promote Treg function. For example some agents as GSK3 inhibitors. These anticancer activity enhances NK cell killing activity and might promote Treg cell function. The clinical trial NCT01632306, NCT01287520, NCT01214603 are demonstrating that GSK3 inhibition in NK cells results in increased TNF-α production by these cells, which upregulates ICAM-1 on AML cells and results in increased NK-AML conjugate formation resulting in enhanced killing of AML cells.
79 months ago
